Pancytopenia Due to Mesantoin

Abstract

SINCE the introduction of Mesantoin (3 methyl-5, 5-phenylethyl-hydantoin) as an anticonvulsant a number of cases of depression of bone marrow, thought to be due to this drug, have been reported.^{1 2 3 4 5} We wish to add another case of pancytopenia due to Mesantoin.Case ReportB. L. Z., a 28-year-old pharmacy student, was admitted to the hospital on August 3, 1948, complaining of multiple bruises, spontaneous nosebleeds, sore throat, chills and fever. In August, 1947, while in bed, he experienced an episode characterized by tonic and clonic movements of the body, arms and legs and subsequent mental confusion. This was diagnosed as . . .