Effects of prostaglandins F-2 and E-2 on cervical extensibility in the late pregnant rat
- 1 January 1980
- journal article
- research article
- Published by Bioscientifica in Reproduction
- Vol. 58 (1), 95-99
- https://doi.org/10.1530/jrf.0.0580095
Abstract
The extensibility of rat cervix was measured in vitro on day 19 of pregnancy and was doubled after 2 s.c. injections of prostaglandin [PG]F2.alpha. (1 mg/kg) or PGE2 (5 mg/kg) on day 18. Progesterone (10 mg/kg) given on day 18 had no effect alone or on the effect of PGE2, but abolished the action of PGF2.alpha.. PGE2, but not PGF2.alpha., increased extensibility when given on day 18 to rats which were bilaterally ovariectomized on day 16 and given estradiol benzoate plus progesterone twice daily. High concentrations of PGE2.alpha. or PGE2 had no effect on the extensibility of day 18 pregnant rat cervix in vitro. PGF2.alpha. evidently acts via the ovaries to decrease progesterone secretion and perhaps release relaxin, but PGE2 would appear to have another site of action.This publication has 5 references indexed in Scilit:
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