N-Acetyltransferase phenotypes in the urinary bladder carcinogenesis of a low-risk population

Abstract

N-Acetyltransferase phenotypes were measured in 228 patients with tumors of the urinary bladder and 100 noncancer controls. Sixty three point six percent of the patients and 54.0% of the controls were slow acetylator phenotypes (P < 0.10). In general, 65% of bladder tumor patients and 59% of controls are slow acetylators (P < 0.025). N-Acetyltransferases are involved in the metabolism of carcinogenic arylamines and thus could be an important factor in interindividual susceptibility to these agents.