CORRELATION OF DNA DISTRIBUTION ABNORMALITIES WITH CYTOGENETIC FINDINGS IN HUMAN ADULT LEUKEMIA AND LYMPHOMA

  • 1 January 1977
    • journal article
    • research article
    • Vol. 37 (12), 4400-4407
Abstract
Pulse cytophotometric analysis of bone marrow cells from 175 patients with leukemia or lymphoma showed abnormalities of cellular DNA distribution in 29 patients for an overall incidence of 16.6%. Comparative standard cytogenetic examination indicated that high-degree chromosomal aberrations (.ltoreq. 44, .gtoreq. 53 chromosomes) can be detected on DNA histograms, whereas patients with diploid, pseudodiploid, 45-hypodiploid and 47-hyperdiploid abnormalities usually escape recognition by this technique. There were 11 patients with normal diploid or near-diploid karyotypes exhibiting marked DNA deviations. This discrepancy may reflect lack of proliferation of some leukemic clones which is a prerequisite for cytogenetic identification.