Long-term Amikacin Use
- 10 September 1982
- journal article
- research article
- Published by American Medical Association (AMA)
- Vol. 248 (10), 1199-1202
- https://doi.org/10.1001/jama.1982.03330100037027
Abstract
Amikacin sulfate was first used sparingly at our cancer center in 1976; since 1979, it has been the only aminoglycoside used for systemic cancer therapy for patients with granulocytopenia. As the development of resistance has been correlated with antibiotic use over time, we wished to determine if prolonged use of amikacin in our patients had led to increased amikacin resistance. A total of 1,129 strains were recovered from 315 patients during a 13-month period. Each species isolated per patient was considered once. Seven percent of the patients had amikacin-resistant strains (2.7% of isolates), and 10% of patients had gentamicin-resistant strains (4% of isolates). Amikacin resistance was significantly less than in an earlier study. Unrestricted use of amikacin has not led to a concomitant increase in amikacin resistance in gram-negative bacilli. (JAMA1982;248:1199-1202)Keywords
This publication has 6 references indexed in Scilit:
- The Classic: Streptomycin, a Substance Exhibiting Antibiotic Activity against Gram-Positive and Gram-Negative BacteriaClinical Orthopaedics and Related Research, 2005
- Role of the membrane potential in bacterial resistance to aminoglycoside antibioticsAntimicrobial Agents and Chemotherapy, 1981
- Emergence of Antibiotic Resistance In Hospitals, 1935-1975Clinical Infectious Diseases, 1979
- Activity of netilmicin against selected strains of Gram-negative bacteria and Staphylococcus aureus: comparison with four other aminoglycosidesJournal of Antimicrobial Chemotherapy, 1977
- Effects of Membrane-Energy Mutations and Cations on Streptomycin and Gentamicin Accumulation by Bacteria: a Model for Entry of Streptomycin and Gentamicin in Susceptible and Resistant BacteriaAntimicrobial Agents and Chemotherapy, 1977
- Inferences concerning proportions.Published by American Psychological Association (APA) ,1953