Macrolide–ketolide inhibition of MLS‐resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA
Open Access
- 1 April 2000
- journal article
- research article
- Published by Wiley in Molecular Microbiology
- Vol. 36 (1), 183-193
- https://doi.org/10.1046/j.1365-2958.2000.01841.x
Abstract
The macrolide antibiotic erythromycin and its 6‐O‐methyl derivative (clarithromycin) bind to bacterial ribosomes primarily through interactions with nucleotides in domains II and V of 23S rRNA. The d...Keywords
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