NEUTROPENIA associated with oral ulcers, periodic fever, benign paroxysmal peritonitis and intermittent arthralgia has been observed to occur with cyclic regularity. In 1949 Reimann and de Berardinis1 reviewed 16 cases from the literature, including one of their own, and concluded that there were grounds for establishing an entity that they designated as a "periodic neutropenia." In the same year, Fullerton and Duguid2 reported a similar case, which they followed for 500 days through 12 attacks of illness characterized by malaise, anorexia, drowsiness, headache, pyrexia and inflammation of the throat and tongue, with painful superficial ulcers of the oral mucosa. They . . .