Einige Beobachtungen über das Wachstum des Mäuse-Ascites-Tumors und seine Beeinflussung

Abstract

Intraperit. inj. in mice of cell suspensions of Ehrlich mouse carcinoma almost always resulted in a large increase of the cancer cells accompanied with much ascites in the abdominal cavity. When this ascitic fluid with the cells was injected into the muscles or skin of other mice, solid tumors were again produced. Mice were also injected intraperit. with 0.2 cc. of the ascitic fluid containing the cancer cells, and the development of the ascitic tumor substance followed by means of the wt. curves of the mice, which rose to a maximum and then decreased until death. Many of the mice died within 3 wks. The tumor cells remained viable in the abdominal cavity of fasting mice, for 8 days or more, but did not proliferate until the animals received food. The rapidity with which the ascitic tumor developed depended upon the strain of mice used, the diet and the amt. of tumor cells in the injected suspension. The inj. of 1 mg. of soluble prontosil/day did not affect the growth of the tumor cells. The inj. of 10[gamma] of colchicine per day delayed the development of the ascitic tumors, but when inj. was stopped, the tumor cells developed as usual.