Eight insulin-dependent diabetic patients were studied on two consecutive mornings when they injected their usual morning mixtures of insulin. One morning they massaged their insulin injection sites 15 min after the injection. Free insulin levels rose 10.14 ± 9.91 μU/ml higher (P < 0.05) and serum glucose levels fell 8.3% lower (P < 0.05) 30 min after massage than on the control study day.