Sodium Salicylate Inhibiting Anti-Rh Immunization in Animals

Abstract

Guinea pigs and rabbits were immunized by the injection of blood cells from Rhesus monkeys. (Rabbits received intraven. injns. of 0.01 ml. of citrated rhesus blood in 1 ml. of saline on the 4th, 5th, 6th, 11th, 12th, and 13th day of the expt.; guinea pigs received 1 ml. of rhesus cells suspended in saline intraperit. on the 3d and 8th day of the expt.) Examination of the sera of the animals 7 days after the last immunizing injn. and 2 days after the last dose of salicylate revealed anti-Rh agglutinins in 71.4% of the 21 animals not treated with salicylate and in only 11.1% of the animals having received salicylate. The absence of free salicyl radical in the sera suggests that sodium salicylate inhibits the formation of anti-Rh agglutinins in vivo.