Immunoblastic Sarcoma in Donor Cells after Bone-Marrow Transplantation

Abstract

THE pathogenesis of lymphomas in man is unknown. A variety of factors are associated with lymphoma induction in animals, including immuno-suppression, immune stimulation, autoimmunity, loss of suppressor T-lymphocyte function, retravirus infection, drugs and irradiation.^{1 2 3} Recently several workers have reported an association between graft-vs.-host disease, activation of endogenous C-type RNA viruses, autoimmunity and lymphomas in susceptible mice.^{4 , 5} In man, a spectrum of immune-related disorders have been associated with malignant lymphomas. These diseases include Sjögren's syndrome, rheumatoid arthritis, polyarteritis, systemic lupus erythematosus and various other autoimmune disorders. Furthermore, in patients receiving immunosuppressive therapy, recipients of renal transplants, there is a marked increase . . .