In Vitro Activity of HR 756, a New Cephalosporin, Against Neisseria gonorrhoeae

Abstract

The in vitro activity of HR 756 was compared with penicillin, cefamandole, cefoxitin and tetracycline against N. gonorrhoeae. A total of 192 randomly selected isolates (of which 23 had minimal inhibitory concentrations of > 0.5 .mu.g/ml for penicillin) and 3 .beta.-lactamase-producing isolates were tested. HR 756 was the most active antibiotic tested, with more than 90% of the isolates inhibited by 0.008 .mu.g/ml and all inhibited by 0.25 .mu.g/ml.