Jaundice Following the Administration of 50 mg. of Chlorpromazine

Abstract

CURRENT interest in chlorpromazine — 10 (ydimethylaminopropyl) -2-chlorophenothiazine —hydrochloride is reflected in the widespread use of this drug in many of the specialties of medicine. First introduced by French workers,^{1 , 2} it has been used for the suppression of nausea and vomiting of varied origin.^{3 4 5} More recently, it has been recommended for the treatment of mental disturbances^{6 , 7} and intractable hiccup.⁸ The known side effects are drowsiness, postural hypotension,⁹ which may lead to renal insufficiency, tachycardia, dryness of the mouth, nasal congestion, pyrosis and constipation. Miosis and sometimes mydriasis, mild increase in temperature, agranulocytosis,^{10 11 12} eosinophilia¹³ and allergic reactions, which are for the . . .