METABOLISM OF 3 CYCLIC NITROSAMINES IN SPRAGUE-DAWLEY RATS
- 1 January 1977
- journal article
- research article
- Vol. 37 (10), 3530-3532
Abstract
The metabolism of 3 [carcinogenic] cyclic nitrosamines was studied in Sprague-Dawley rats. The compounds were nitrosopyrrolidine, nitrosohexamethyleneimine and nitrosoheptamethyleneimine and were labeled at the .alpha.-C with 14C. At low doses (2-4 mg/animal) the compounds were metabolized to 14CO2 to the extent of 77, 43 and 27%, respectively, after 24 h. At doses closer to the LD50 of the compounds (70-160 mg/animal) the metabolism values were only 14, 4 and 8%, respectively, after 24 h. The significance of these results is discussed.This publication has 4 references indexed in Scilit:
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