Vertebrate collagenase inhibitor. I. Tripeptidyl hydroxamic acids.

Abstract
A series of tripeptidyl analogues carrying hydroxamic acid residue at the C-terminus of the molecule were synthesized, and their inhibitory activities against vertebrate collagenase and other metalloenzymes including bacterial collagense were examined. Both Z-Pro-Leu-Ala-NHOH and z-Pro-D-Leu-D-Ala-NHOH showed highly specific and potent inhibitory activity against tadpole and human skin collagenases with an IC50 of 10-6 M order.