ANTAGONISM OF THE EFFECTS OF TREMORINE BY TROPINE DERIVATIVES
Open Access
- 1 December 1959
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 14 (4), 559-566
- https://doi.org/10.1111/j.1476-5381.1959.tb00964.x
Abstract
Methods of testing new drugs for anti-Parkinson activity are briefly reviewed. The production in animals of Parkinson-like effects by Tremorine (1,4-dipyrrolidin-1′-ylbut-2-yne), and the inhibition of these effects in mice by a number of tropine derivatives, are described. No correlation was found between the activity against tremor and the anticholinergic, antihistaminic or local anaesthetic properties of the compounds.Keywords
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