DR Typing in Australian Aborigines. An Indication for a Second Locus in the HLA-D Region Defined by Serology

Abstract

A group of 43 Australian aborigines was typed for HLA-DR determinants and other antigens on B cells, using pregnancy sera from Caucasoid women. The group could not be considered as random, since a selection was made for an equal number of Au antigen positive and Au antigen negative individuals. The typing results showed that the specificities DRw2, 4 and 8 were as well defined in this population as in Caucasoids, whereas the specificities DRw1, 3, 5 and 7 could not be defined. Even more interesting was the finding that a cluster of 6 sera, defining the local B cell specificity LB12, gave positive reactions in 41 of 43 aborigines. Although LB12 is found to be highly associated with DRw1, 2 and 6 in the Caucasoid population, in 36 cases the LB12 positive aborigines could not be demonstrated to carry the specificities DRw1 or 2. The recognition of DRw6 is difficult at the moment and for that reason its presence or absence in this material is uncertain. However, 3 individuals typed positive for DRw4 and 8 and for LB12 as well. The hypothesis that the genes coding for LB12 and its postulated allele LB13 are separate from the genes coding for the known DR determinants is supported. LB12 is very likely identical to the recently described determinants DC1 (Tosi and Tanigaki, 1979) and MB1 (Duquesnoy et al., 1979a).