Several major episodes of Tertiary explosive volcanism coincided with sharply lowered temperature as inferred from oxygen-isotope composition of foraminiferal tests in deep-sea cores. At these times, fossil floras in the western interior recorded significant changes. Reductions in taxa that required warmth occurred early in the Paleogene. Later, taxa that demand ample summer rain were reduced during a progressive change reflecting growth of the subtropic high. Other ecosystem changes that appear to have responded to volcanically induced climatic modifications include tachytely in Equidae (12–10 m.y. B.P.), rapid evolution of grasses (7–5 m.y. B.P.), evolution of marine mammals, and plankton fluctuations. Although Late Cretaceous extinctions commenced as epeiric seas retreated, the pulses of sharply lowered temperature induced by explosive volcanism, together with widespread falls of volcanic ash, may have led to extinction of dinosaurs, ammonites, cycadeoids, and other Cretaceous taxa. Earlier, as Pangaea was assembled, Permian extinctions resulted not only from the elimination of oceans, epeiric seas, and shorelines, and the spread of more-continental climates, but also from the climatic effects of major pulses of global volcanism and Gondwana glaciation.