BETA-CYCLODEXTRIN - PROMOTING EFFECT ON THE DEVELOPMENT OF RENAL TUBULAR CELL TUMORS IN RATS TREATED WITH N-ETHYL-N-HYDROXYETHYLNITROSAMINE

Abstract

Injection (s.c.) of .beta.-cyclodextrin (.beta.-C) increased the number and size of renal tubular cell tumors in inbred Wistar (W) rats treated with 1000 ppm of N-ethyl-N-hydroxyethylnitrosamine (EHEN). The incidence of renal tumors at the end of the 32 wk experiment was 50% in rats treated with 1000 ppm EHEN for 2 wk and 100% in rats treated with 1000 ppm EHEN for 2 wk and then given daily s.c. injections of .beta.-C for 1 wk. The incidence of renal tumors > 3 mm in diameter was 70% in rats treated with 1000 ppm EHEN before .beta.-C but 0% in rats treated with EHEN alone. .beta.-C promoted the development of renal tumors in rats treated with 500 ppm EHEN, which is a subthreshold dose for renal tubular cell tumorigenesis. These results show that .beta.-C promotes EHEN-induced renal tubular cell tumorigenesis.