Metabolic and Hemodynamic Changes Induced by the Prolonged Administration of Dextran

Abstract

Large amounts of dextran were administered to human subjects under standardized metabolic conditions, with the following results: Dextran is a potent osmotic substance which produces marked salt and water retention and rapid plasma volume expansion. About 50 per cent of the amount given is excreted in the urine during the injection period. Nitrogen and phosphorus sparing and an antiketogenic effect are produced during the period of administration. A fraction of the dextran remains circulating for a prolonged period of time and is associated with a sustained depression of venous hematocrit. Metabolism of this fraction cannot be demonstrated, and its ultimate fate in the body is unknown.