NON-ADENOMATOUS INAPPROPRIATE TSH HYPERSECRETION AND EUTHYROIDISM REQUIRES NO TREATMENT
- 1 October 1987
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 27 (4), 475-483
- https://doi.org/10.1111/j.1365-2265.1987.tb01176.x
Abstract
The syndrome of inappropriate TSH secretion is described in a euthyroid girl and her father. Based on nuclear T3 binding studies in fibroblasts, generalized tissue resistance was associated with a lower binding affinity for T3 in nuclear extracts suggestive of a structurally abnormal receptor for T3. Early recognition of the syndrome and observation of the short‐term response to thyroid medication prevented unnecessary trials of antithyroid medication and later radical ablative thyroid treatment.This publication has 20 references indexed in Scilit:
- Characterization of nuclear thyroid hormone receptors of cultured skin fibroblasts from patients with resistance to thyroid hormoneMetabolism, 1987
- Complete Androgen Insensitivity Syndrome Characterized by Increased Concentration of a Normal Androgen Receptor in Genital Skin Fibroblasts*Journal of Clinical Endocrinology & Metabolism, 1986
- AUGMENTATION OF ANDROGEN‐RECEPTOR BINDING IN VITRO: STUDIES IN NORMALS AND PATIENTS WITH ANDROGEN INSENSITIVITYClinical Endocrinology, 1985
- A New Case of Familial Partial Generalized Resistance to Thyroid Hormones: Study of 3,5,3′-Triiodothyronine (T3) Binding to Lymphocyte and Skin Fibroblast Nuclei andin VivoConversion of Thyroxine to T3*Journal of Clinical Endocrinology & Metabolism, 1984
- Successful treatment of hyperthyroidism due to nonneoplastic pituitary TSH hypersecretion with 3,5,3′-triiodothyroacetic acid (TRIAC)Journal of Endocrinological Investigation, 1983
- THE EFFECTS OF TETRAIODOTHYROACETIC AND TRIIODOTHYROACETIC ACIDS ON THYROID FUNCTION IN EUTHYROID AND HYPERTHYROID SUBJECTSActa Endocrinologica, 1979
- The Epidermal Response to Change in Thyroid StatusJournal of Investigative Dermatology, 1977
- Familial Partial Target Organ Resistance to Thyroid HormonesJournal of Clinical Endocrinology & Metabolism, 1976
- Thyrotropin-induced hyperthyroidism caused by selective pituitary resistance to thyroid hormone. A new syndrome of "inappropriate secretion of TSH".JCI Insight, 1975
- Partial Target Organ Resistance to Thyroid HormoneJCI Insight, 1973