Coronary capillary permeability and tissue volumes for sucrose and water in dogs: a comparison of bolus and constant infusion multiple-indicator methods

Abstract

This study was undertaken to determine the accuracy with which heart interstitial and water volumes could be determined from multiple-indicator dilution experiments on the coronary circulation in open-chest dog preparations. Sucrose permeability by extraction calculations was found to average 0.26± 0.02 cm³·(min.g tissue)⁻¹. The extravascular sucrose volume averaged 0.15 cm³·g⁻¹ tissue by both multiple-indicator and post-mortem methods. Indicator-dilution tritiated water curves labelled 85% of the post-mortem water content.