Blockage by Adenovirus E4orf6 of Transcriptional Activation by the p53 Tumor Suppressor
- 7 June 1996
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 272 (5267), 1470-1473
- https://doi.org/10.1126/science.272.5267.1470
Abstract
The adenovirus E4orf6 protein is shown here to interact with the cellular tumor suppressor protein p53 and to block p53-mediated transcriptional activation. The adenovirus protein inhibited the ability of p53 to bind to human TAFII31, a component of transcription factor IID (TFIID). Earlier work demonstrated that the interaction of p53 with TAFII31 involves a sequence near the NH2-terminus of p53, whereas the E4orf6-p53 interaction occurs within amino acids 318 to 360 of p53. Thus, the E4orf6 protein interacts at a site on p53 distinct from the domain that binds to TAFII31 but nevertheless inhibits the p53-TAFII31 interaction.Keywords
This publication has 32 references indexed in Scilit:
- Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinasesNature, 1995
- Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminusCell, 1995
- Allosteric activation of latent p53 tetramersCurrent Biology, 1994
- Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.Genes & Development, 1994
- WAF1, a potential mediator of p53 tumor suppressionCell, 1993
- Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53Nature, 1993
- Regulation of the specific DNA binding function of p53Cell, 1992
- Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.Genes & Development, 1992
- The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivationCell, 1992
- Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cellsCell, 1982