An ultrastructural study of transganglionic degeneration in the main sensory trigeminal nucleus of the rat

Abstract

In adult rats subjected to unilateral transection of the infraorbital nerve, the main sensory trigeminal nucleus was studied by electron microscopy. Post-operative survival times varied between 2 and 60 days. A variety of ultrastructural alterations was observed from the sixth postoperative day onwards. These changes were in many respects similar to those seen in the course of Wallerian degeneration. Neurofilamentous boutons and axons were found 6–30 days post-operatively. Various types of dark boutons were observed between 7 and 30 days and axonal changes indicative of degeneration between 7 and 60 days post-operatively. Astrocytes and microglial cells contained degenerating structures 7–60 days post-operatively. The alterations observed in the present study are interpreted as related, at least in part, to the nerve cell degeneration and the nerve cell death previously shown to occur in the trigeminal ganglion after infraorbital nerve transection.