Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion‐induced necrosis and apoptosisin vivo
- 1 February 2000
- journal article
- Published by Wiley in The FASEB Journal
- Vol. 14 (2), 418-429
- https://doi.org/10.1096/fasebj.14.2.418
Abstract
Reperfusion of ischemic tissue results in the generation of reactive oxygen species that contribute to tissue injury. The sources of reactive oxygen species in reperfused tissue are not fully chara...Keywords
Funding Information
- Johns Hopkins University
This publication has 51 references indexed in Scilit:
- The Vav–Rac1 Pathway in Cytotoxic Lymphocytes Regulates the Generation of Cell-mediated KillingThe Journal of Experimental Medicine, 1998
- Protection from reoxygenation injury by inhibition of rac1.Journal of Clinical Investigation, 1998
- Role of Oxidants in Ischemic Brain DamageStroke, 1996
- Ischemic Stroke and Incomplete InfarctionStroke, 1996
- Lipid peroxidation as molecular mechanism of liver cell injury during reperfusion after ischemiaFree Radical Biology & Medicine, 1994
- A Simplified Method for the Preparation of Transcriptionally Active Liver Nuclear ExtractsDNA and Cell Biology, 1990
- Free Radicals and Their Involvement During Long-Term Myocardial Ischemia and ReperfusionAnnual Review of Physiology, 1990
- Hypoxic damage generates reactive oxygen species in isolated perfused rat liverBiochemical and Biophysical Research Communications, 1988
- Failure of the xanthine oxidase inhibitor allopurinol to limit infarct size after ischemia and reperfusion in dogs.Circulation, 1985
- Oxygen-Derived Free Radicals in Postischemic Tissue InjuryNew England Journal of Medicine, 1985