EFFECTS OF ENDOTOXIN ON THE HEMODYNAMICS OF THE STOMACH*

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Abstract
Hemodynamic effects of endotoxin on a perfused canine stomach preparation were investigated. The injection of Salmonella typhosa endotoxin induced portal venous hypertension, systemic arterial hypotension and an increase in the resistance to blood flow across the stomach. When the gastric circulation was isolated from the systemic, endotoxin failed to elicit the gastric vascular resistance changes when injected into either the gastric or general circulation. This suggests that the action of endotoxin upon the circulation of the stomach is mediated through neurohumoral agents released at sites distant from the stomach.