THE EFFECT OF SULPHASALAZINE WITHDRAWAL ON RECTAL MUCOSAL FUNCTION AND PROSTAGLANDIN-E2 RELEASE IN INACTIVE ULCERATIVE-COLITIS
- 1 January 1981
- journal article
- research article
- Vol. 16 (1), 157-159
Abstract
Rectal dialysis was used in vivo to assess mucosal prostaglandin E2 (PGE2) release and water and electrolyte transport before and 2 wk after withdrawal of oral sulfasalazine in 8 patients with inactive ulcerative colitis. Although rectal mucosal PGE2 release was unaffected by withdrawal of sulfasalazine, significant reductions in mucosal potential difference (P < 0.01) and net absorption of water (P < 0.05), Na (P < 0.05) and Cl occurred (P < 0.05%). Clinical assessment showed no change in disease activity. Sulfasalazine withdrawal has a detrimental effect on large intestinal salt and water transport, which apparently is not mediated through changes in net mucosal prostaglandin production.This publication has 4 references indexed in Scilit:
- Saturation kinetics applied to in vitro effects of low prostaglandin E2 and F2α concentrations on ion transport across human jejunal mucosaGastroenterology, 1980
- Prostaglandin synthetase activity in acute ulcerative colitis: effects of treatment with sulphasalazine, codeine phosphate and prednisolone.Gut, 1979
- Determination of prostaglandin synthetase activity in rectal biopsy material and its significance in colonic disease.Gut, 1978
- ROLE OF PROSTAGLANDINS IN ULCERATIVE-COLITIS - ENHANCED PRODUCTION DURING ACTIVE DISEASE AND INHIBITION BY SULFASALAZINE1978