PspC, a Pneumococcal Surface Protein, Binds Human Factor H
Open Access
- 1 May 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (5), 3435-3437
- https://doi.org/10.1128/iai.69.5.3435-3437.2001
Abstract
PspC was found to bind human complement factor H (FH) by Western blot analysis of D39 (pspC +) and an isogenic mutant TRE108 (pspC). We confirmed that PspA does not bind FH, while purified PspC binds FH very strongly. The binding of FH to exponentially growing pneumococci varied among different isolates when analyzed by fluorescence activated cell sorting analysis.Keywords
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