Trace Element Contamination of Intravenous Solutions

Abstract

The trace element content of various intravenous solutions was investigated, using atomic absorption and neutron activation analysis methods. The variable content of zinc, calcium, and magnesium led us to seek a source of contamination. Quantities of zinc ranging from 10.75μg to 132μg were leached from the rubber stoppers when placed in 0.1N nitric acid for a period of 96 hours. Calcium and magnesium were also leached from the stoppers, but in lesser amounts. (Arch Intern Med 136:782-784, 1976)