Characterizing the Relationship Between HIV‐1 Genotype and Phenotype: Prediction‐Based Classification
- 1 March 2002
- journal article
- Published by Oxford University Press (OUP) in Biometrics
- Vol. 58 (1), 145-156
- https://doi.org/10.1111/j.0006-341x.2002.00145.x
Abstract
Summary. This paper establishes a framework for understanding the complex relationships between HIV-1 genotypic markers of resistance to antiretroviral drugs and clinical measures of disease progression. A new classification scheme based on the probabilities of how new patients will respond to antiretroviral therapy given the available data is proposed as a method for distinguishing among groups of viral sequences. This approach draws from existing cluster analysis, discriminant analysis, and recursive partitioning techniques and requires a model relating genotypic characteristics to phenotypic response. A data set of 2746 sequences and the corresponding Indinavir 50% inhibitory concentrations are described and used for illustrative purposes.This publication has 22 references indexed in Scilit:
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