Occurrence of Convulsive Seizures during Treatment of Asthma with Cortisone Acetate

Abstract

CORTISONE is being used in a wide variety of clinical conditions. This drug has profound physiologic effects, and occasional undesirable reactions are to be expected.Several observers have noted convulsive seizures in patients receiving the adrenocorticotrophic hormone (ACTH) of the pituitary body, which is closely related in its effects to Cortisone, but to our knowledge no such case is recorded in the literature. Some of these patients suffered from diseases that are known to cause seizures occasionally. In others the seizures have been ascribed to contamination of the preparation with hormone from the posterior pituitary body or to cerebral edema . . .