Chronic Renal Failure in Children Treated with Methyl CCNU
- 24 May 1979
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 300 (21), 1200-1203
- https://doi.org/10.1056/nejm197905243002106
Abstract
METHYL CCNU (1- [2-chloroethyl] -3-[4-methyl cyclohexylj-1-nitrosourea) has been used to treat a variety of solid tumors1 2 3 for more than six years.4 It has been shown to be effective and to have an acceptable acute toxicity — mild gastrointestinal irritability and reversible bone-marrow suppression.1 The appearance of two patients previously treated with methyl CCNU in the end-stage renal-disease program at Children's Hospital Medical Center led us to review the effects of treatment with the drug at this hospital and at the Sidney Farber Cancer Institute. Our review disclosed a high incidence of renal failure in patients who had received methyl CCNU. . . .Keywords
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