Clonal deletion of V β814-bearing T cells in mice transgenic for mammary tumour virus
- 1 March 1991
- journal article
- Published by Springer Nature in Nature
- Vol. 350 (6315), 207-211
- https://doi.org/10.1038/350207a0
Abstract
Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V beta 14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.Keywords
This publication has 36 references indexed in Scilit:
- Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumour virus genomesNature, 1991
- An endogenous retrovirus mediating deletion of αβ T cells?Nature, 1991
- Linkage of Mls genes to endogenous mammary tumour viruses of inbred miceNature, 1991
- A maternally inherited superantigen encoded by a mammary tumour virusNature, 1991
- Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunityCell, 1990
- T cell tolerance by clonal elimination in the thymusCell, 1987
- A T cell receptor Vβ segment that imparts reactivity to a class II major histocompatibility complex productCell, 1987
- Strong histocompatibility and cell‐mediated cytotoxic effects of a single Mls difference demonstrated using a new congenic mouse strainEuropean Journal of Immunology, 1983
- Cloned mouse mammary tumor virus DNA is biologically active in transfected mouse cells and its expression is stimulated by glucocorticoid hormonesCell, 1981
- Mammary tumor induction loci in GR and DBAf mice contain one provirus of the mouse mammary tumor virusCell, 1981