Hormonal Mechanisms in Nervous Mechanism of Gastric Acid Secretion in Humans

Abstract

Conclusions 1. The peak of elevation of gastric acidity in the intact stomach following insulin injection occurs significantly later than that of pepsin and mucoprotein, and 30-45 minutes after the maximal fall in blood sugar. 2. The acid stimulating effect of insulin is diminishled and of ten abolished following resection of the dis'tal end of the stomach while the pepsin and mucoprotein response are undiminished. 3. These observations add further strength to already existing evidence that while vagal stimuli appear to affect directly the glandular cells which secrete pepsin and mucoprotein and may act in part directly on the parietal cells, they also effect an increased elaboration of HC1 in the human stomach by the intermediation of another mechanism that may involve the hormone “gastrin”.