Angiotensin II Type 2 Receptor Inhibits Cell Proliferation and Activates Tyrosine Phosphatase

Publisher Website
Google Scholar
Abstract
The angiotensin II type 2 (AT 2 ) receptor inhibits basic fibroblast growth factor–induced proliferation of R3T3 fibroblast cells and transiently stimulates a vanadate-sensitive phosphotyrosine phosphatase, strongly suggesting that AT 2 is a mitogen inhibitor. We generated AT 2 gene–null mice that showed increased blood pressure, indicating the hypotensive action of AT 2 . However, inhibition of renomedullary AT 2 by selective antagonists, as reported by Sassard and associates, show that AT 2 suppresses pressure natriuresis. Thus, both AT 1 and AT 2 work in the direction of sodium retention, suggesting a unique role for angiotensin II in the kidney in terms of blood pressure regulation and sodium metabolism.