Local Ovarian Effects of an Intrauterine Device in Intact and Unilaterally Ovariectomized Guinea Pigs.

Abstract

Summary The effects of an intrauterine device (IUD) on the corpora lutea, estrous cycle length and ovulation rate were studied in guinea pigs. Insertion of an IUD on day 2 of an estrous cycle resulted in smaller corpora lutea in the ovary adjacent to the IUD than in the opposite ovary. The average estrous cycle length was shortened in ovarian-intact guinea pigs with an IUD in each uterine horn and in unilaterally ovariectomized guinea pigs with the IUD adjacent to the retained ovary. Estrous cycles were not shortened in ovarian-intact guinea pigs with an IUD in only one horn or in unilaterally ovariectomized guinea pigs with the IUD opposite to the retained ovary. No evidence was obtained that the IUD influenced the rate of ovulation.