Effects of 15‐hydroperoxyeicosatetraenoic acid on human lymphocyte sheep erythrocyte rosette formation and response to concanavalin A associated with HLA system
- 1 January 1982
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 12 (9), 773-777
- https://doi.org/10.1002/eji.1830120913
Abstract
The lipoxygenase product hydroperoxyeicosatetraenoic acid (HPETE) has immunosuppressive properties in vitro and in vivo. It was observed that 15‐HPETE inhibit the sheep red blood cell rosette formation and the concanavalin A‐induced blast transformation of human lymphocytes. This inhibition was HLA‐linked. HLA‐B12 subjects were less sensitive than non‐B12 subjects. It is likely that HPETE acids are macrophage mediators which inhibit some lymphocyte functions.This publication has 7 references indexed in Scilit:
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