Embryotoxicity induced by alkylating agents
- 1 January 1983
- journal article
- research article
- Published by Springer Nature in Archives of Toxicology
- Vol. 52 (1), 45-69
- https://doi.org/10.1007/bf00317981
Abstract
Acetoxymethyl-methylnitrosamine, the acetate ester of the presumed reactive metabolite of dimethylnitrosamine, is an effective teratogen in NMRI mice. An unusual phenomenon of application route specificity and a pronounced phase specificity of the teratogenic effects induced are demonstrated. Dose-response relationships are established. Some further arguments are given to support the basic hypothesis that the teratogenicity of alkylating agents is closely correlated to the DNA alkylation rate of embryonic cells.This publication has 34 references indexed in Scilit:
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