Facile and Selective Cleavageof Allyl Ethers Based on Palladium(0)-Catalyzed Allylic AlkylationofN,N′-DimethylbarbituricAcid

Abstract

The classical palladium(0)-catalyzed allylic alkylation of N,N′-dimethylbarbituric acid can be applied to the facile and selective cleavage of allylic alkyl ethers to release the corresponding alcohols in excellent yield. This reaction proceeds under neutral conditions without any additive to activate the allyl ethers and tolerates various functional groups, such as ester, ether, ketone, alkyl and aryl chloride, nitrile and nitro groups.