TC-99M HMPAO STEREOISOMERS AS POTENTIAL AGENTS FOR IMAGING REGIONAL CEREBRAL BLOOD-FLOW - HUMAN VOLUNTEER STUDIES

  • 1 February 1986
    • journal article
    • research article
    • Vol. 27 (2), 171-177
Abstract
A total of nine normal volunteer subjects were studied with three forms of [99mTc]hexamethylpropyleneamineoxime (HM-PAO), a potential cerebral blood flow imaging agent. One, the d,l isomer, showed 4.1% uptake in the brain which remained constant over 8 hr. There was good differentiation between uptake in grayu and white matter on tomographic slices. We propose that this agent may allow regional cerebral flow imaging to be performed on a routine basis.