Early Rheumatoid-Like Joint Lesions in Rabbits Injected with Foreign Serum
- 1 January 1981
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 65 (1), 114-120
- https://doi.org/10.1159/000232746
Abstract
Intradermal injection of rabbits with lipid-coupled bovine serum proteins or bovine serum itself prior to a regimen of intravenous injections of bovine serum enhanced the incidence of joint lesions over that seen in animals receiving the intravenous regimen only. This increased incidence of synovial lesions appeared, however, to be unrelated, either to the state of delayed hypersensitivity or to the concentration of passive haemagglutinating antibodies to bovine serum proteins in these animals. Lipid-coupled bovine serum, given as a first course in a regimen of intravenous injections, was no more arthritogenic than the native proteins and, as a second course series of intravenous injections, was definitely less arthritogenic.Keywords
This publication has 3 references indexed in Scilit:
- Early Rheumatoid-Like Joint Lesions in Rabbits Injected with Foreign Serum or Milk ProteinsInternational Archives of Allergy and Immunology, 1980
- Rheumatoid-Like Joint Lesions in Rabbits Injected Intravenously with Bovine SerumInternational Archives of Allergy and Immunology, 1977
- Humoral and cellular responses to native antigen following oral and parenteral immunization with lipid-conjugated bovine serum albuminCellular Immunology, 1976