Sympathoexcitation by Oxidative Stress in the Brain Mediates Arterial Pressure Elevation in Salt-Sensitive Hypertension
- 1 August 2007
- journal article
- research article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 50 (2), 360-367
- https://doi.org/10.1161/hypertensionaha.107.091009
Abstract
Central sympathoexcitation is involved in the pathogenesis of salt-sensitive hypertension. We have suggested that oxidative stress in the brain modulates the sympathetic regulation of arterial pressure. Thus, we investigated whether oxidative stress could mediate central sympathoexcitation in salt-sensitive hypertension. Five- to 6-week-old male Dahl salt-sensitive rats and salt-resistant rats were fed with a normal (0.3%) or high- (8%) salt diet for 4 weeks. In urethane-anesthetized and artificially ventilated rats, arterial pressure, renal sympathetic nerve activity, and heart rate decreased in a dose-dependent fashion, when 20 or 40 μmol of tempol, a membrane-permeable superoxide dismutase mimetic, was infused into the lateral cerebral ventricle. The same degree of reduction was noted in salt-sensitive and salt-resistant rats without salt loading. Salt loading significantly increased central tempol-induced reductions in arterial pressure (−29.1±4.8% versus −10.6±3.3% at 40 μmol; P P P phox , p47 phox , and gp91 phox mRNA expression significantly increased in the hypothalamus of salt-loaded salt-sensitive rats. In conclusion, in salt-sensitive hypertension, increased oxidative stress in the brain, possibly via activation of reduced nicotinamide-adenine dinucleotide phosphate oxidase, may elevate arterial pressure through central sympathoexcitation.Keywords
This publication has 32 references indexed in Scilit:
- Protective Effect of Potassium Against the Hypertensive Cardiac DysfunctionHypertension, 2006
- Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential hypertensionJournal Of Hypertension, 2006
- 11β-Hydroxysteroid Dehydrogenase Type 2 Activity in Hypothalamic Paraventricular Nucleus Modulates Sympathetic ExcitationHypertension, 2006
- NADPH Oxidase in the Renal Medulla Causes Oxidative Stress and Contributes to Salt-Sensitive Hypertension in Dahl S RatsHypertension, 2006
- Effect of Salt on Isoprostanes in Salt-Sensitive Essential HypertensionHypertension, 2006
- NADPH Oxidase–Derived Superoxide Anion Mediates Angiotensin II–Induced Pressor Effect via Activation of p38 Mitogen–Activated Protein Kinase in the Rostral Ventrolateral MedullaCirculation Research, 2005
- Expression and regulation of adrenomedullin in renal glomerular podocytesBiochemical and Biophysical Research Communications, 2005
- Increased Reactive Oxygen Species in Rostral Ventrolateral Medulla Contribute to Neural Mechanisms of Hypertension in Stroke-Prone Spontaneously Hypertensive RatsCirculation, 2004
- The Effect of Weight Loss on the Sensitivity of Blood Pressure to Sodium in Obese AdolescentsNew England Journal of Medicine, 1989
- Role of sympathetic nervous system in hypotensive action of taurine in DOCA-salt rats.Hypertension, 1987