Increased Lecithin Synthesis during Phagocytosis by Normal Leukocytes and by Leukocytes of a Patient with Chronic Granulomatous Disease

Abstract

Study of incorporation of albumin-bound lysolecithin-³²P into lecithin of human leukocytes (from peripheral blood) during ingestion of inert particles revealed that significantly more lysolecithin was incorporated than at rest. This stimulation of lecithin synthesis accounts for substantial addition of new lecithin and may be important for membrane formation during phagocytosis.