Development of Bile Acid Biogenesis in the Rat: Effect of Neonatal Thyroidectomy, Adrenalectomy, and Streptozotocin-Induced Diabetes

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Abstract
Effect of neonatal thyroidectomy, adrenalectomy and streptozotocin-induced diabetes in rats on the bile acid pool size and composition at weaning was examined. Adrenalectomy caused a significant (p < 0.05) decrease in the total bile acid pool with significant reductions (p < 0.05) in both cholic and chenodeoxycholic acids. Thyroidectomy on the other hand caused a specific decrease (p < 0.05) in chenodeoxycholic acid pool. Streptozotocin-induced diabetes caused (a) a decrease (p < 0.05) in total bile acid pool with a significant (p < 0.05) reduction in chenodeoxycholic acid, and (b) an increase in plasma cholesterol levels.