Absorption and excretion of pheniodol labelled with radioactive iodine

Abstract

Single doses of pheniodol labelled with I131 were administered orally, subcut. and intraven. to rats, and the excretion of radioactive I studied over a 3-day period. After oral dosage about 50% of the administered radioactive I was excreted in the feces and 25% in the urine. After subcut. injn. 40% of the dose appeared in the feces and 20% in the urine. After intraven. injn. 50% of the dose appeared in the feces and 30% in the urine. A single dose of labelled pheniodol was injected intraven. and intraduodenally into anesthetized cats, and the radioactive iodine blood levels and biliary and urinary excretion rates were measured over a 6 hr. period. After an intraven. injn. 20% of the dose was excreted in bile and 33% in the urine; after an intraduodenal injn. 36% appeared in the bile and 9% in the urine.