Interactions of Benzodiazepines with Warfarin
- 9 September 1972
- Vol. 3 (5827), 611-614
- https://doi.org/10.1136/bmj.3.5827.611
Abstract
Administration of nitrazepam (10 mg nightly), diazepam (15 mg/day), and chlordiazepoxide (15 and 30 mg/day) had no effect on steady-state plasma warfarin concentrations, the plasma half-life of warfarin, or anticoagulant control in patients and it appears safe to prescribe these agents to patients on long-term oral anticoagulants. Urinary excretion of 6 β-hydroxycortisol, however, increased in two out of five patients given chlordiazepoxide. In rats pretreatment with chlordiazepoxide (40 mg/kg for four days) caused stimulation of liver microsomal enzyme activity but neither diazepam nor nitrazepam had this effect.Keywords
This publication has 10 references indexed in Scilit:
- CLINICAL IMPLICATIONS OF ENZYME INDUCTIONAnnals of the New York Academy of Sciences, 1971
- Drug Interactions with Warfarin: Studies with Dichloralphenazone, Chloral Hydrate and Phenazone (Antipyrine)Clinical Science, 1971
- The assay of warfarin in plasma or stoolBiochemical Medicine, 1970
- Interaction of Commonly Prescribed Drugs and WarfarinAnnals of Internal Medicine, 1970
- The Effect of Librium on HemostasisThe American Journal of the Medical Sciences, 1968
- CHANGES IN PLASMA CORTISOL INDUCED BY DEXAMPHETAMINE AND CHLORDIAZEPOXIDE GIVEN ALONE AND IN COMBINATION IN MANJournal of Endocrinology, 1968
- The effect of some sedatives (phenobarbital, gluthetimide, chlordiazepoxide, chloral hydrate) on the rate of disappearance of ethyl biscoumacetate from the plasma.1967
- Metabolism and tolerance studies with chlordiazepoxide-2-14C in the ratToxicology and Applied Pharmacology, 1966
- Induction of liver microsomal cortisol 6β-hydroxylase by diphenylhydantoin or phenobarbital: An explanation for the increased excretion of 6-hydroxycortisol in humans treated with these drugsLife Sciences, 1965
- THROMBOTEST A NEW METHOD FOR CONTROLLING ANTICOAGULANT THERAPYThe Lancet, 1959