QUALITATIVE DIFFERENCES IN GONADOTROPHIC EXTRACTS FROM URINE OF POST-MENOPAUSAL WOMEN

Abstract

SUMMARY: 1. A gonadotrophic preparation made from post-menopausal human urine with tannic acid had more activity on the mouse uterus than would be predicted from the results of the test on the prostate of the hypophysectomized rat. 2. In one experiment, when gonadotrophic principles were adsorbed on kaolin at pH 6 from a very concentrated solution of post-menopausal gonadotrophin in distilled water, even larger quantitative differences were found in the results of these two tests. 3. There was no significant deviation of the dose-response curves from parallelism in either test. 4. The data suggest that there is more than one gonadotrophin in post-menopausal urine.