The Effects of Septic Complications upon the Serum Protein Changes Associated with Thermal Injury
- 1 July 1985
- journal article
- research article
- Published by SAGE Publications in Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
- Vol. 22 (4), 391-396
- https://doi.org/10.1177/000456328502200411
Abstract
The levels of 12 serum proteins including ‘acute-phase reactants’, immunoglobulins and albumin were measured in 20 patients suffering from thermal burns. The acute-phase reactants: C-reactive protein, α-1 antitrypsin, α-1 antichymotrypsin, haptoglobin and orosomucoid, all increased in concentration. Highest levels, which showed significant correlations with injury severity, occurred at 6–8 days post-burn. The levels of albumin, α-1 lipoprotein and transferrin were decreased. The immunoglobulins IgG, IgA and IgM showed an initial decrease followed by a steady return to normal levels. Four patients, of whom three died, developed serious sepsis. The levels of α-1 antichymotrypsin and C-reactive protein were much higher in patients with sepsis than in those without sepsis. The highest levels occurred during and often before the episode of sepsis was clinically evident. The immunoglobulins especially IgG and IgA were lower in those patients who developed sepsis than in those who did not. The results suggest that the serum levels of either C-reactive protein or α-1 antichymotrypsin could be used both as an aid to diagnosis of sepsis and also to monitor the effect of therapy.This publication has 11 references indexed in Scilit:
- Changes in the serum concentrations of thyroxine-binding prealbumin and retinol-binding protein following burn injuryClinica Chimica Acta; International Journal of Clinical Chemistry, 1982
- C-reactive protein for rapid diagnosis of infection in leukaemia.Journal of Clinical Pathology, 1979
- Serum C-reactive protein test in diagnosis of septic complications of cerebrospinal fluid shunts for hydrocephalus.Archives of Disease in Childhood, 1979
- Albumin turnover in burns and traumaPublished by Springer Nature ,1976
- SERUM PROTEIN PROFILES IN THERMAL BURNS II. Protease Inhibitors, Complement Factors, and C-Reactive ProteinPublished by Wolters Kluwer Health ,1974
- Modifications to the Technique of Two-Dimensional ImmunoelectrophoresisClinical Science, 1971
- THE TURNOVER RATE OF OROSOMUCOID IN BURNED PATIENTSPublished by Wolters Kluwer Health ,1970
- CHANGES IN IMMUNOGLOBULIN LEVELS IN SEVERELY BURNED PATIENTSThe Lancet, 1969
- Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodiesAnalytical Biochemistry, 1966
- Immunochemical quantitation of antigens by single radial immunodiffusionImmunochemistry, 1965