Changes in cerebral glucose metabolism with normal aging
- 20 January 1997
- journal article
- Published by Wiley in European Journal of Neurology
- Vol. 4 (1), 8-14
- https://doi.org/10.1111/j.1468-1331.1997.tb00294.x
Abstract
The pattern of changes in cerebral glucose metabolism occurring with normal aging has been unclear. Advances in imaging technology, such as improved resolution and anatomical referencing, allow for more precise regional measurement than previously possible. This study explored cerebral glucose metabolism in 17 normal controls ranging in age from 20 to 74 years. High resolution PET scanning, with MRI-based regions of interest correcting for partial volume and atrophy effects, revealed a linear association between advancing age and declining cerebral glucose metabolism. The decline averaged 8% per decade for the whole brain. Changes were most pronounced in limbic structures, and could be implicated in age-associated memory loss.Keywords
This publication has 33 references indexed in Scilit:
- Precision and Accuracy Considerations of Physiological Quantitation in PETJournal of Cerebral Blood Flow & Metabolism, 1991
- The effect of focal cerebral atrophy in positron emission tomographic studies of aging and dementiaNuclear Medicine and Biology, 1989
- Anterograde and Retrograde Amnesia in Patients With Chronic Progressive Multiple SclerosisArchives of Neurology, 1988
- Differential memory function with dopaminergic versus anticholinergic treatment of drug-induced extrapyramidal symptomsAmerican Journal of Psychiatry, 1988
- Controlling for Cerebral Atrophy in Positron Emission Tomography DataJournal of Cerebral Blood Flow & Metabolism, 1987
- Human Cerebral Glucose Metabolism Determined by Positron Emission Tomography: A RevisitJournal of Cerebral Blood Flow & Metabolism, 1987
- Human brain glucose utilization and cognitive function in relation to ageAnnals of Neurology, 1984
- Clinical correlates of dementia and disability in Huntington's diseaseJournal of Clinical Neuropsychology, 1984
- Positron Emission Tomography and Computed Tomography Assessments of the Aging Human BrainJournal of Computer Assisted Tomography, 1984
- CEREBRAL GLUCOSE UTILIZATION, AS MEASURED WITH POSITRON EMISSION TOMOGRAPHY IN 21 RESTING HEALTHY MEN BETWEEN THE AGES OF 21 AND 83 YEARSBrain, 1983