Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens.
Open Access
- 1 June 1988
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 167 (6), 2005-2010
- https://doi.org/10.1084/jem.167.6.2005
Abstract
The cellular basis of neonatally induced T cell tolerance has been investigated in a model system in which usage of a particular TCR V.beta. segment (V.beta.6) is strongly correlated with reactivity to antigens encoded by the Mlsa genetic locus. Expression of V.beta.6 by peripheral T cells was virtually abolished in BALB/c (H-2d, Mlsb) mice rendered neonatally tolerant to DBA/2 (H-2d, Mlsa) lymphoid cells, whereas control V.beta.8-bearing T cells remained at near normal levels. Further analysis revealed that elimination of V.beta.6+ T cells occurred in the thymus of neonatally tolerant mice and could not be explained by receptor modulation or T cell chimerism. These data thus support the clonal deletion model of tolerance induction.This publication has 12 references indexed in Scilit:
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